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Updated: May 20, 2026
06:23
Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo
Published on: August 4, 2018
Coagulation profile of liquid-state plasma
Robert C Gosselin1, Carol Marshall, Denis M Dwyre
1Department of Medical Pathology and Laboratory Medicine, the Trauma Division, University of California, Davis Health System, Sacramento, California 95817, USA.
Transfusion
|August 1, 2012
Summary
Liquid plasma (LP) retains over 50% of coagulation factor activity for 15 days under refrigeration. This suggests limiting LP storage and considering fresh-frozen plasma (FFP) for massive hemorrhage management.
Area of Science:
- Transfusion Medicine
- Hematology
- Coagulation Science
Background:
- Liquid plasma (LP) is stored at 1–6°C for extended periods, unlike fresh-frozen plasma (FFP).
- The coagulation profile of LP, despite FDA approval, remains incompletely characterized.
- This study investigates the coagulation properties of LP stored for up to 30 days.
Purpose of the Study:
- To evaluate the coagulation profile of liquid plasma (LP) during refrigerated storage.
- To determine the duration of adequate coagulation factor activity in LP.
Main Methods:
- Liquid plasma (LP) was prepared from whole blood and stored at 1–6°C.
- Aliquots were collected on days 1, 5, 10, 15, 20, 25, and 30 for analysis.
- Prothrombin time, activated partial thromboplastin time, and various coagulation/fibrinolytic factors were measured.
Main Results:
- Significant decreases in Factor V, Factor VII, Factor VIII, von Willebrand factor, and Protein S activity were observed by Day 15.
- Endogenous thrombin potential also decreased significantly by Day 15.
- Over 50% activity for measured factors was maintained at Day 15, with notable inter-blood group heterogeneity for FVII, FVIII, and VWF.
Conclusions:
- Liquid plasma (LP) maintains at least 50% of its coagulation factor activity and thrombin generation capacity for up to 15 days of refrigerated storage.
- Extended storage beyond 15 days may compromise efficacy.
- Supplementation with fresh-frozen plasma (FFP) may be necessary for managing massively bleeding patients receiving LP.
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