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Updated: May 20, 2026
07:32
Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Polymeric particulate technologies for oral drug delivery and targeting: a pathophysiological perspective
A Christy Hunter1, Jacqueline Elsom, Peter P Wibroe
1University of Manchester, Department of Pharmacy and Pharmaceutical Sciences, Stopford Building, Oxford Road, Manchester, M13 9PT, United Kingdom. christy.hunter@manchester.ac.uk
Nanomedicine : Nanotechnology, Biology, and Medicine
|August 1, 2012
Summary
Polymeric nanoparticles and microparticles enhance oral drug delivery. This review explores their interactions and fate within the gastrointestinal system, focusing on advanced nanocarrier technologies.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Biotechnology
Background:
- Oral drug delivery is the most common pharmaceutical administration route.
- Nanoparticles and microparticles are emerging as key technologies to improve oral drug targeting and bioavailability.
- Polymeric materials are frequently utilized in the construction of these advanced drug delivery systems.
Purpose of the Study:
- To review cutting-edge nanocarrier technologies for oral drug delivery.
- To specifically examine the interaction and fate of polymeric nanocarriers within the gastrointestinal system.
Main Methods:
- Literature review of current nanocarrier technologies.
- Analysis of studies focusing on polymeric nanoparticles, solid lipid nanocarriers, self-nanoemulsifying drug delivery systems, and nanocrystals.
- Examination of research on the gastrointestinal fate and interactions of these materials.
Main Results:
- Detailed description of various polymeric nanocarrier systems.
- Insights into the behavior and degradation pathways of these carriers in the gastrointestinal environment.
- Understanding the impact of gastrointestinal conditions on nanocarrier performance and drug release.
Conclusions:
- Polymeric nanocarriers represent a significant advancement in oral pharmaceutical delivery.
- Understanding their gastrointestinal fate is crucial for optimizing drug efficacy and safety.
- Further research into nanocarrier-gastrointestinal interactions will drive innovation in drug delivery.
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