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Updated: May 20, 2026

Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans
Published on: December 19, 2014
Sarcoid-like reaction in Cryptococcus neoformans infection
Shuichi Yano1, Kanako Kobayashi, Toshikazu Ikeda
1Department of Pulmonary Medicine, National Hospital Organization Matsue Medical Center, Matsue, Japan. yano@matsue.hosp.go.jp
Abstract:
We report a patient with Cryptococcus (C.) neoformans infection, who developed a case of sarcoid-like reaction (SLR). There have been reports of SLRs associated with malignancies. Although differentiating sarcoidosis from SLR is difficult, the patient was diagnosed as SLR because propionibacterium acnes bacterial (PAB) antibody staining of biopsy specimens was negative and the chest radiological findings improved after antifungal treatment. To our knowledge, this is the first report of SLR occurring during cryptococcal infection, and we believe that cryptococcal infection should be considered as a potential cause of SLR.
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