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Related Experiment Video

Updated: May 20, 2026

Preparation of Rat Tail Tendons for Biomechanical and Mechanobiological Studies
15:12

Preparation of Rat Tail Tendons for Biomechanical and Mechanobiological Studies

Published on: July 30, 2010

Eccentric training improves tendon biomechanical properties: a rat model.

Jean-François Kaux1, Pierre Drion, Vincent Libertiaux

  • 1Physical Medicine Service and Department of Motility Sciences, University Hospital of Liège, University of Liège, Avenue de 1'Hôpital, B35, B-4000 Liege, Belgium. jfkaux@chu.ulg.ac.be

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
|August 1, 2012
PubMed
Summary

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This summary is machine-generated.

Eccentric training significantly enhances tendon strength and collagen content in rats, improving mechanical properties. This study clarifies how eccentric loading aids tendon healing and adaptation.

Area of Science:

  • Biomechanical Engineering
  • Sports Medicine
  • Histology

Background:

  • Tendinopathies are commonly treated with eccentric reeducation, but underlying biomechanical changes remain unclear.
  • The physiology of tendon adaptation to mechanical loading requires further elucidation.
  • Mechanotransduction is a key theory, yet tendon physiology is not fully understood.

Purpose of the Study:

  • To define biomechanical and histological changes in healthy rat tendons after eccentric and concentric training.
  • To compare the effects of eccentric (E) versus concentric (C) training on tendon properties.
  • To investigate the impact of training on tendon rupture force, cross-sectional area, and mechanical stress.

Main Methods:

  • Rats underwent 5 weeks of eccentric (E), concentric (C), or no (U) training.

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Last Updated: May 20, 2026

Preparation of Rat Tail Tendons for Biomechanical and Mechanobiological Studies
15:12

Preparation of Rat Tail Tendons for Biomechanical and Mechanobiological Studies

Published on: July 30, 2010

Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats
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Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats

Published on: March 30, 2018

Biomechanical Testing of Murine Tendons
10:09

Biomechanical Testing of Murine Tendons

Published on: October 15, 2019

  • Tensile tests were performed on tricipital, patellar, and Achilles tendons to determine rupture force and mechanical stress.
  • Histological analysis using hematoxylin and eosin and Masson's trichrome stains assessed tissue changes.

    • Main Results:

    • Eccentric training significantly increased rupture force in patellar and tricipital tendons compared to untrained controls.
    • Tricipital tendons showed increased cross-sectional area in both E and C groups versus the untrained group.
    • Histology revealed increased vascularization and collagen content in tendons following eccentric training.

    Conclusions:

    • Eccentric training demonstrably improves the mechanical properties of rat tendons.
    • Increased collagen and vascularization in the eccentric group suggest enhanced tissue repair and adaptation.
    • These findings provide mechanistic insights into how eccentric loading promotes tendon healing.