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Related Experiment Video

Updated: May 20, 2026

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
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Cognitive dysfunction in early multiple sclerosis: altered centrality derived from resting-state functional

Martin Hardmeier1, Menno M Schoonheim, Jeroen J G Geurts

  • 1Department of Clinical Neurophysiology, VU University Medical Center, Amsterdam, The Netherlands. mhardmeier@uhbs.ch

Plos One
|August 1, 2012
PubMed
Summary

Cognitive dysfunction in multiple sclerosis (MS) is linked to altered brain network connectivity. Temporal region disconnection and parietal hub shifts may underlie cognitive deficits, particularly in male patients.

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Neurology

Background:

  • Cognitive dysfunction is a common and debilitating symptom in multiple sclerosis (MS).
  • Understanding the neural mechanisms of MS-related cognitive impairment is crucial for developing targeted therapies.

Purpose of the Study:

  • To investigate the relationship between cognitive performance and brain network topology in early relapsing-remitting MS.
  • To utilize magneto-encephalography (MEG) to analyze nodal centrality patterns and their association with cognitive function.

Main Methods:

  • 34 early MS patients and 28 healthy controls (HC) underwent MEG, neuropsychological testing, and MRI.
  • Resting-state functional connectivity was assessed using synchronization likelihood, and Eigenvector Centrality (EC) quantified network importance.
  • EC was compared between groups across frequency bands and correlated with cognitive scores.

Main Results:

  • MS patients exhibited reduced grey and white matter volumes compared to HC.
  • In HC, EC peaked at bi-parietal sensors; MS patients showed increased bi-parietal centrality (theta-band) but decreased left temporal centrality (alpha/beta-bands).
  • Lower cognitive performance correlated with reduced temporal centrality and increased right parieto-temporal centrality, with more pronounced network changes in male patients.

Conclusions:

  • Partial functional disconnection in temporal regions is associated with cognitive impairment in MS.
  • Increased centrality in parietal hubs may indicate a compensatory but less efficient processing shift.
  • Longitudinal studies are needed to track network dynamics and gender influences on MS cognitive changes.