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Adult BMI Change and Risk of Colon Cancer in Postmenopausal Women
Lyla Blake-Gumbs1, Zhengyi Chen, Cheryl L Thompson
1Department of Family Medicine and Community Health, School of Medicine, Case Western Reserve University, Cleveland, OH 44106-7136, USA.
Journal of Obesity
|August 1, 2012
Summary
Weight gain in adulthood is linked to a higher risk of colon cancer, particularly in postmenopausal women not using hormone replacement therapy (HRT). This association highlights the importance of weight management for cancer prevention.
Area of Science:
- Oncology
- Epidemiology
- Public Health
Background:
- Adult body mass index (BMI) change has been previously associated with colon cancer risk.
- Further investigation is needed to understand this association in relation to postmenopausal hormone replacement therapy (HRT) use.
Purpose of the Study:
- To explore the association between adult BMI change and colon cancer risk in postmenopausal women.
- To investigate the modifying role of HRT use on this association.
Main Methods:
- A population-based case-control study included 1,457 postmenopausal women.
- Data on BMI changes since the 20s and 30s, and HRT use were collected.
- Statistical analyses, including stratified analyses, were performed to assess risk.
Main Results:
- A significant association was confirmed between adulthood weight gain and increased colon cancer risk (P for trend = 0.05).
- This association was primarily observed in HRT non-users, with higher BMI changes correlating with increased odds ratios (ORs).
- No significant association was found among HRT users.
Conclusions:
- Early adulthood weight gain appears to increase colon cancer risk in postmenopausal women who do not use HRT.
- HRT use may mitigate the association between weight gain and colon cancer risk.
- Findings underscore the importance of weight management for colon cancer prevention in specific postmenopausal populations.
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