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Copper(I)-catalyzed amination of aryl halides in liquid ammonia

Pengju Ji1, John H Atherton, Michael I Page

  • 1IPOS, The Page Laboratories, Department of Chemical and Biological Sciences, University of Huddersfield, Queensgate, Huddersfield, HD1 3DH, UK.

The Journal of Organic Chemistry
|August 2, 2012
PubMed

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Aminolysis is a nucleophilic acyl substitution reaction, where ammonia or amines act as nucleophiles to give the substitution product. Acid halides react with ammonia, primary amines, and secondary amines to yield primary, secondary, and tertiary amides, respectively.
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