Related Experiment Video
Updated: May 20, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
Tenosynovial giant cell tumor: case report and review
1Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA. drlucas@umich.edu
Abstract:
Tenosynovial giant cell tumors are a group of generally benign intra-articular and soft tissue tumors with common histologic features. They can be roughly divided into localized and diffuse types. Localized types include giant cell tumors of tendon sheath and localized pigmented villonodular synovitis, whereas diffuse types encompass conventional pigmented villonodular synovitis and diffuse-type giant cell tumor. Localized tumors are generally indolent, whereas diffuse tumors are locally aggressive. Recent developments indicate that tenosynovial giant cell tumors are clonal neoplastic tumors driven by overexpression of CSF1. Herein, I report a case of intra-articular, localized tenosynovial giant cell tumor (or localized pigmented villonodular synovitis) and review the classification, histopathology, and recent developments regarding its pathogenesis.
Related Concept Videos
Cytotoxic Edema: Pathophysiology
Cushing Syndrome I: Introduction
Cushing Syndrome II: Pathophysiology
Nephrotic Syndrome I : Introduction
Pericarditis I: Introduction