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Published on: December 1, 2020
Dipeptidyl peptidase-4 inhibitor with β-amino amide scaffold: synthesis, SAR and biological evaluation
Heung Jae Kim1, Woo Young Kwak, Jong Pil Min
1Dong-A Pharm. Co., Ltd, 47-5, Sanggal-dong, Giheung-gu, Yongin-si, Gyeonggi-do 446-905, Republic of Korea.
Abstract:
Inhibitors of dipeptidyl peptidase-4 (DPP4) have been shown to be effective treatments for type 2 diabetes. Several series of β-amino amide containing piperazine derivatives have been prepared and evaluated as a inhibitor of DPP4. Finally compound 5m was selected for further evaluation.
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