Related Experiment Video

Updated: May 20, 2026

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage
10:34

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

Published on: August 30, 2020

Subarachnoid hemorrhage caused by ruptured intracranial fusiform aneurysm associated with microscopic polyangiitis

Hidehito Kimura1, Nobuyuki Akutsu, Ryoji Shiomi

  • 1Department of Neurosurgery, Toyooka Public Hospital, Hyogo, Japan. hidekimura-nsu@umin.ac.jp

Neurologia Medico-Chirurgica
|August 2, 2012
PubMed

Insights

Microscopic polyangiitis (MPA) can cause rare cerebral aneurysms. This case highlights MPA

Area of Science:

  • Neurology
  • Nephrology
  • Rheumatology

Background:

  • Microscopic polyangiitis (MPA) typically affects small vessels in the kidneys and lungs.
  • Cerebral aneurysms are an extremely rare manifestation of MPA.

Observation:

  • A 44-year-old woman with MPA presented with a ruptured cerebral aneurysm and progressive renal failure.
  • Initial treatment for a posterior inferior cerebellar artery (PICA) aneurysm recurred, necessitating a second intervention with bypass.
  • The patient subsequently developed crescentic glomerulonephritis and pulmonary hemorrhage, confirming MPA diagnosis.

Findings:

  • Successful treatment of a recurrent PICA aneurysm with bypass and trapping.
  • Histological confirmation of crescentic glomerulonephritis, a known complication of MPA.
  • Patient discharged without neurological deficit after intensive treatment for MPA complications.

Implications:

  • This case underscores the importance of considering rare vascular complications like cerebral aneurysms in MPA patients.
  • Screening for intracranial aneurysms using magnetic resonance imaging is recommended for patients with MPA.
  • Prompt diagnosis and management of MPA-related glomerulonephritis and hemorrhage are crucial for patient outcomes.

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