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Related Concept Videos

Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
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Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
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Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

Published on: August 1, 2018

Keratin expression in breast cancers.

Mu-Min Shao1, Siu Ki Chan, Alex M C Yu

  • 1Department of Pathology, Shenzhen Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, Shenzhen, China.

Virchows Archiv : an International Journal of Pathology
|August 2, 2012
PubMed
Summary
This summary is machine-generated.

Cytokeratin (CK) immunohistochemistry aids breast cancer evaluation. Specific CK panels, like CK8 and CK7, effectively identify cancer cells and correlate with tumor grade and subtypes, offering diagnostic and prognostic insights.

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Area of Science:

  • Oncology
  • Pathology
  • Biomarker Research

Background:

  • Cytokeratin (CK) immunohistochemistry is crucial for breast carcinoma evaluation.
  • Understanding CK expression patterns aids in diagnosing and subtyping breast cancers.

Purpose of the Study:

  • To evaluate a panel of commonly used CKs in a large breast cancer cohort.
  • To assess the correlation of CK expression with other biomarkers and breast cancer subtypes.
  • To determine the diagnostic and prognostic relevance of CK expression patterns.

Main Methods:

  • Immunohistochemical analysis of CK7, CK8, CK18, CK19, CK5/6, CK14, and CK20 expression in breast carcinomas.
  • Correlation analysis with established biomarkers and molecular subtypes.
  • Evaluation of CK sensitivity for detecting small numbers of cancer cells.

Main Results:

  • CK7, CK8, CK18, and CK19 were expressed in over 90% of breast carcinomas, confirming their utility.
  • A combination of CK8 and CK7 demonstrated high sensitivity for detecting minimal cancer cell populations.
  • CK5/6, CK14, and CK20 expression correlated with high tumor grade.
  • CK5/6 showed a higher detection rate for the basal subtype than CK14.
  • Increased CK20 expression was linked to poor prognosis and the molecular apocrine subtype.

Conclusions:

  • Specific CK panels are effective for breast cancer identification and characterization.
  • CK expression patterns provide valuable diagnostic and prognostic information.
  • CK profiles can aid in differentiating subtypes and predicting outcomes.