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Updated: May 20, 2026

Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities
Published on: October 27, 2023
Multimodality image fusion-guided procedures: technique, accuracy, and applications
Nadine Abi-Jaoudeh1, Jochen Kruecker, Samuel Kadoury
1Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, USA. naj@mail.nih.gov
Abstract:
Personalized therapies play an increasingly critical role in cancer care: Image guidance with multimodality image fusion facilitates the targeting of specific tissue for tissue characterization and plays a role in drug discovery and optimization of tailored therapies. Positron-emission tomography (PET), magnetic resonance imaging (MRI), and contrast-enhanced computed tomography (CT) may offer additional information not otherwise available to the operator during minimally invasive image-guided procedures, such as biopsy and ablation. With use of multimodality image fusion for image-guided interventions, navigation with advanced modalities does not require the physical presence of the PET, MRI, or CT imaging system. Several commercially available methods of image-fusion and device navigation are reviewed along with an explanation of common tracking hardware and software. An overview of current clinical applications for multimodality navigation is provided.
Insights
Multimodality image fusion enhances cancer care by enabling precise image-guided interventions. This technology integrates data from PET, MRI, and CT scans for improved tissue characterization and targeted therapies.
Area of Science:
- Medical Imaging
- Oncology
- Interventional Radiology
Background:
- Personalized cancer therapies are crucial for effective treatment.
- Image guidance is essential for precise targeting in minimally invasive procedures.
- Multimodality imaging offers complementary information for complex interventions.
Purpose of the Study:
- To review image fusion techniques and navigation systems for image-guided interventions.
- To explain the role of advanced imaging modalities in cancer care.
- To provide an overview of current clinical applications of multimodality navigation.
Main Methods:
- Review of commercially available image-fusion and device navigation systems.
- Explanation of tracking hardware and software used in image-guided interventions.
- Discussion of the integration of Positron-emission tomography (PET), Magnetic Resonance Imaging (MRI), and Computed Tomography (CT) data.
Main Results:
- Multimodality image fusion allows for advanced navigation without the physical presence of imaging systems.
- Image fusion facilitates accurate tissue characterization and targeting for biopsies and ablations.
- The technology supports drug discovery and optimization of tailored cancer therapies.
Conclusions:
- Multimodality image fusion is a key technology for advancing personalized cancer care.
- It enhances the capabilities of image-guided interventions, improving precision and efficiency.
- The integration of various imaging modalities provides valuable data for clinical decision-making and therapeutic optimization.
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