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Mite-induced inflammation: More than allergy.

Mario Sánchez-Borges, Enrique Fernández-Caldas, Arnaldo Capriles-Hulett

Allergy & Rhinology (Providence, R.I.)

|August 2, 2012

Summary

Patients with atopic conditions and mite allergy often experience hypersensitivity reactions to nonsteroidal anti-inflammatory drugs (NSAIDs). This suggests a link between atopy, mite allergy, and NSAID intolerance, possibly involving leukotriene pathways.

Keywords:

Aspirin Dermatophagoides NSAIDs acetylsalicylic acid angioedema cysteinyl-leukotrienes immunoglobulin E leukotriene C4 synthase mites nonsteroidal anti-inflammatory drugs

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Area of Science:

Immunology
Allergology
Pharmacology

Background:

Clinical observations suggest a link between atopic conditions and hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs).
This association is particularly noted in patients with mite allergies.

Purpose of the Study:

To review clinical and experimental evidence connecting atopy, mite allergy, and hypersensitivity to aspirin and NSAIDs.
To discuss potential mechanisms underlying this observed association.

Main Methods:

A comprehensive review of the medical literature was conducted using PubMed and other relevant databases.
The review focused on studies examining the relationship between atopic diseases, mite hypersensitivity, and NSAID intolerance.

Main Results:

NSAID-sensitive patients frequently exhibit atopy and mite allergy.
Patients with oral mite anaphylaxis (OMA) show a higher prevalence of NSAID hypersensitivity.
An interaction between atopic allergy and leukotriene synthesis/metabolism disorders is suggested.

Conclusions:

The association between mite hypersensitivity and aspirin/NSAID intolerance is confirmed.
This finding offers insights into non-IgE-mediated pathways contributing to inflammation in atopic, mite-allergic individuals.
Further investigation into the clinical relevance of these findings is ongoing.