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Mite-induced inflammation: More than allergy

Mario Sánchez-Borges, Enrique Fernández-Caldas, Arnaldo Capriles-Hulett

    Allergy & Rhinology (Providence, R.I.)
    |August 2, 2012
    PubMed

    Insights

    Patients with atopic conditions and mite allergy often experience hypersensitivity reactions to nonsteroidal anti-inflammatory drugs (NSAIDs). This suggests a link between atopy, mite allergy, and NSAID intolerance, possibly involving leukotriene pathways.

    Area of Science:

    • Immunology
    • Allergology
    • Pharmacology

    Background:

    • Clinical observations suggest a link between atopic conditions and hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs).
    • This association is particularly noted in patients with mite allergies.

    Purpose of the Study:

    • To review clinical and experimental evidence connecting atopy, mite allergy, and hypersensitivity to aspirin and NSAIDs.
    • To discuss potential mechanisms underlying this observed association.

    Main Methods:

    • A comprehensive review of the medical literature was conducted using PubMed and other relevant databases.
    • The review focused on studies examining the relationship between atopic diseases, mite hypersensitivity, and NSAID intolerance.

    Main Results:

    • NSAID-sensitive patients frequently exhibit atopy and mite allergy.
    • Patients with oral mite anaphylaxis (OMA) show a higher prevalence of NSAID hypersensitivity.
    • An interaction between atopic allergy and leukotriene synthesis/metabolism disorders is suggested.

    Conclusions:

    • The association between mite hypersensitivity and aspirin/NSAID intolerance is confirmed.
    • This finding offers insights into non-IgE-mediated pathways contributing to inflammation in atopic, mite-allergic individuals.
    • Further investigation into the clinical relevance of these findings is ongoing.
    Keywords:
    AspirinDermatophagoidesNSAIDsacetylsalicylic acidangioedemacysteinyl-leukotrienesimmunoglobulin Eleukotriene C4 synthasemitesnonsteroidal anti-inflammatory drugs

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