Probabilities of orders in linkage calculations
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1Galton Laboratory, University College London.
Annals of Human Genetics
|October 1, 1990
Abstract:
The present state of linkage estimation procedures is surveyed. When information on linkage between several loci on one chromosome is given in the form of lod scores or likelihoods, a method is developed for finding the probabilities of the different possible orders of the loci, and the distribution of the map distances between them. This depends largely on a Monte Carlo method of integrating the probabilities.