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Related Experiment Video

Updated: May 19, 2026

Fast and Specific Assessment of the Halogenating Peroxidase Activity in Leukocyte-enriched Blood Samples
05:17

Fast and Specific Assessment of the Halogenating Peroxidase Activity in Leukocyte-enriched Blood Samples

Published on: July 28, 2016

Myeloperoxidase levels predict executive function.

H Haslacher1, T Perkmann, I Lukas

  • 1Department of Laboratory Medicine, Medical University of Vienna, Austria. helmuth.haslacher@akhwien.at

International Journal of Sports Medicine
|August 3, 2012
PubMed
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High myeloperoxidase (MPO) levels negatively impact executive function in elderly athletes, despite high physical activity. This suggests strenuous exercise may induce oxidative stress, outweighing exercise benefits for cognitive health.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Gerontology

Background:

  • Physical activity is generally beneficial for cognitive function.
  • Myeloperoxidase (MPO) is an enzyme involved in inflammation and oxidative stress.
  • The relationship between MPO levels, physical activity, and cognitive function in elderly individuals is not fully understood.

Purpose of the Study:

  • To investigate the association between baseline myeloperoxidase (MPO) levels and executive cognitive function in elderly individuals with high physical activity.
  • To compare these associations in marathon runners versus a control group.

Main Methods:

  • Serum MPO levels were measured using ELISA in 56 elderly marathon runners and 58 controls.
  • Executive cognitive function was assessed using standardized tests (e.g., NAI maze test, Trail Making Test).

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Last Updated: May 19, 2026

Fast and Specific Assessment of the Halogenating Peroxidase Activity in Leukocyte-enriched Blood Samples
05:17

Fast and Specific Assessment of the Halogenating Peroxidase Activity in Leukocyte-enriched Blood Samples

Published on: July 28, 2016

The Examination of Peroxidase-Positive Leukocytes in Semen
04:36

The Examination of Peroxidase-Positive Leukocytes in Semen

Published on: January 19, 2024

  • Brain morphology was evaluated using magnetic resonance imaging (MRI).

    • Main Results:

    • Higher baseline MPO levels correlated with poorer executive cognitive function in marathon runners, but not in controls.
    • Specific tests showing significant correlations included the NAI maze test (p<0.05) and Trail Making Test ratio (p<0.01).
    • Subcortical white matter hyperintensities were linked to depression scores in controls, an effect not observed in athletes.

    Conclusions:

    • Elevated MPO levels may counteract the cognitive benefits of high physical activity in elderly athletes.
    • Strenuous exercise might increase MPO and pro-inflammatory mediators, leading to oxidative stress and potential tissue damage.
    • This oxidative stress could negatively impact cognitive function, even in physically active individuals.