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Related Experiment Videos

Topical and systemic antibiotics: is there a rationale?

W C Noble1

  • 1Division of Dermatology, United Medical School, University of London, England, UK.

Seminars in Dermatology
|December 1, 1990
PubMed
Summary

Choosing between topical and systemic antibiotic therapy for skin diseases requires balancing efficacy, cost, and antibiotic resistance. This analysis explores rational selection criteria for bacterial skin infections and non-infections.

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Area of Science:

  • Dermatology
  • Infectious Diseases
  • Pharmacology

Background:

  • Topical and systemic antibiotic use is prevalent in dermatology.
  • Selecting the optimal antibiotic route for specific skin conditions can be challenging.
  • Factors influencing route selection include efficacy, cost, and potential for antibiotic resistance.

Purpose of the Study:

  • To provide a rationale for choosing between topical and systemic antibiotic therapy in dermatology.
  • To discuss the interplay of efficacy, cost, and antibiotic resistance in treatment decisions.
  • To analyze these factors in the context of both infectious and noninfectious bacterial skin diseases.

Main Methods:

  • Literature review and critical analysis of existing data.
  • Discussion of pharmacological principles related to antibiotic delivery.
  • Consideration of economic factors and antimicrobial stewardship.

Main Results:

  • Efficacy varies significantly based on drug penetration and disease severity.
  • Cost-effectiveness differs between routes, impacting accessibility.
  • The risk of developing antibiotic resistance is a critical consideration for both topical and systemic treatments.

Conclusions:

  • Rational antibiotic selection in dermatology necessitates a comprehensive evaluation of efficacy, cost, and resistance.
  • Understanding these factors is crucial for optimizing treatment outcomes and minimizing adverse effects.
  • Further research may be needed to establish definitive guidelines for specific dermatological conditions.

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