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Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
Published on: December 21, 2019
[Malignant peritoneal mesothelioma].
Cláudia Cardoso1, Elia Gamito, Carlos Quintana
1Serviço de Gastrenterologia e de Anatomia Patológica, Centro Hospitalar de Setúbal, Setúbal, Portugal.
Acta Medica Portuguesa
|August 4, 2012
Summary
Malignant peritoneal mesothelioma, a rare cancer, was diagnosed in a woman presenting with ascites. Treatment involved cytoreductive surgery and hyperthermic intraperitoneal chemotherapy, leading to a positive outcome.
Area of Science:
- Oncology
- Surgical Oncology
- Gastroenterology
Background:
- Malignant peritoneal mesothelioma is a rare neoplasm originating from the peritoneum.
- Ascites of unknown origin can be a presenting symptom.
Observation:
- A female patient presented with ascites of unknown etiology.
- Initial investigations were inconclusive, necessitating diagnostic laparoscopy.
- Laparoscopy revealed multiple peritoneal nodules, with biopsies confirming malignant peritoneal mesothelioma.
Findings:
- Histological examination confirmed the diagnosis of malignant peritoneal mesothelioma.
- The patient underwent cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC).
Implications:
- This case highlights the importance of diagnostic laparoscopy in unexplained ascites.
- Combined cytoreductive surgery and HIPEC represent a viable treatment strategy for malignant peritoneal mesothelioma.
- The patient remained asymptomatic four months post-treatment, suggesting treatment efficacy.

