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Intestinal Obstruction II: Pathophysiology01:07

Intestinal Obstruction II: Pathophysiology

Intestinal obstruction triggers a series of physiological responses, starting with gas and fluid accumulation in the bowel segment proximal to the obstruction, leading to distension. This distended intestine compresses the diaphragm, hindering lung expansion and potentially leading to reduced respiratory effort, atelectasis, and pneumonia.To overcome the blockage, the gut intensifies contractions, causing colicky abdominal pain, nausea, and vomiting, which reduces fluid and food intake and...
Intestinal Obstruction I: Introduction01:29

Intestinal Obstruction I: Introduction

Intestinal obstruction is a partial or complete blockage of the small or large intestine that disrupts the normal flow of intestinal contents through the lumen. This interruption impairs digestion, absorption, and fluid balance, and may lead to serious complications if not treated promptly.Mechanical ObstructionMechanical obstruction occurs when a physical blockage prevents intestinal contents from passing, arising from within the lumen or the bowel wall, or from external compression.Adhesions,...
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Diverticular Disease of the Colon01:27

Diverticular Disease of the Colon

Diverticular disease involves the formation of diverticula—small sac-like outpouchings of the colonic wall—and their complications. It most commonly affects the sigmoid colon due to higher intraluminal pressure and structural vulnerability. It results from structural weakness and increased pressure in the colon, producing pseudodiverticula that may remain silent or progress to inflammation and serious complications.Structure of DiverticulaIn diverticulosis, these outpouchings are...
Pyloric Obstruction01:11

Pyloric Obstruction

Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...
Appendicitis01:19

Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...

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Related Experiment Video

Updated: May 19, 2026

A Mouse Model of Intestinal Partial Obstruction
07:33

A Mouse Model of Intestinal Partial Obstruction

Published on: March 5, 2018

Intestinal prolapse through a persistent omphalomesenteric duct causing small-bowel obstruction.

Ghislain Pauleau1, Diane Commandeur, Christophe Andro

  • 1Department of Digestive Surgery, Hôpital Laveran, France. ghislainpauleau@yahoo.fr

South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
|August 4, 2012
PubMed
Summary

Persistent omphalomesenteric duct caused a rare case of small-bowel obstruction in a neonate. Surgical resection of the duct remnant led to an uncomplicated recovery, highlighting effective management strategies.

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Ileectomy-induced Bile Overaccumulation in Mouse Intestine
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Ileectomy-induced Bile Overaccumulation in Mouse Intestine

Published on: August 21, 2017

Related Experiment Videos

Last Updated: May 19, 2026

A Mouse Model of Intestinal Partial Obstruction
07:33

A Mouse Model of Intestinal Partial Obstruction

Published on: March 5, 2018

Ileectomy-induced Bile Overaccumulation in Mouse Intestine
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Ileectomy-induced Bile Overaccumulation in Mouse Intestine

Published on: August 21, 2017

Area of Science:

  • Pediatric Surgery
  • Gastrointestinal Surgery
  • Neonatal Medicine

Background:

  • The omphalomesenteric duct (OMD) is a remnant of the omphalomesenteric duct, connecting the midgut to the umbilical vesicle.
  • A persistent omphalomesenteric duct can lead to various gastrointestinal complications, though small-bowel obstruction is exceptionally rare.

Observation:

  • A neonate presented with clinical signs of small-bowel obstruction.
  • Imaging and surgical exploration revealed intestinal prolapse through a persistent omphalomesenteric duct.

Findings:

  • The persistent omphalomesenteric duct was identified as the cause of the intestinal occlusion.
  • Surgical resection of the omphalomesenteric duct remnant was performed successfully.

Implications:

  • This case underscores the importance of considering persistent omphalomesenteric duct in the differential diagnosis of neonatal small-bowel obstruction.
  • Prompt surgical intervention is crucial for favorable outcomes in such rare presentations.
  • Understanding the embryological remnants is vital for diagnosing and managing complex neonatal surgical conditions.