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Expedient synthesis of norbenzomorphan library via multicomponent assembly process coupled with ring-closing
James J Sahn1, Stephen F Martin
1Department of Chemistry and Biochemistry, The Texas Institute for Drug and Diagnostic Development, The University of Texas , Austin, Texas 78712, United States.
Abstract:
A 124-member norbenzomorphan library has been prepared utilizing a novel multicomponent assembly process (MCAP) followed by a variety of ring-closing reactions to generate norbenzomorphan scaffolds that were readily derivatized via a series of aryl halide cross-coupling and nitrogen functionalization reactions. Biological screening has revealed some novel activities that have not been previously associated with this class of compounds.
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