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Related Experiment Video

Updated: May 19, 2026

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Published on: April 13, 2017

Physiological function of microglia.

Hiroaki Wake¹, R Douglas Fields

¹Nervous System Development and Plasticity Section, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA. hirowake@nibb.ac.jp

Neuron Glia Biology

|August 4, 2012

Summary

This summary is machine-generated.

Microglia, immune cells in the brain, are now recognized for their crucial role in building neural circuits. This research highlights their function in healthy brain physiology, moving beyond their known role in disease.

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Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

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Published on: January 30, 2014

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Last Updated: May 19, 2026

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

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Published on: April 13, 2017

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

Area of Science:

Neuroscience
Neuroimmunology
Cell Biology

Background:

Microglia are traditionally known for their roles in brain immunity and pathology.
Recent research indicates microglia have functions beyond immune responses.
Understanding microglial roles in normal brain function is an emerging area.

Purpose of the Study:

To explore the expanding understanding of microglial functions in the brain.
To highlight the involvement of microglia in neural circuit development and physiology.
To present recent findings on microglial contributions to normal brain function.

Main Methods:

This special issue compiles research articles and reviews.
Methods likely include in vivo and in vitro studies, genetic models, and advanced imaging techniques.
The collection focuses on synthesizing current knowledge and future directions.

Main Results:

Microglia play a significant role in the formation and refinement of neural circuits.
Their functions extend into the normal physiological processes of the brain.
New appreciation for microglia's impact on synaptic plasticity and neuronal connectivity.

Conclusions:

Microglial involvement in neural circuit development is a rapidly advancing field.
The traditional view of microglia solely in pathology is outdated.
Further research into microglial roles in brain health is warranted.