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Encapsulation of liver microsomes--a further procedure for detoxication
E Brugmann1, J Strange, D Falkenhagen
1Department of Pathological Biochemistry, Wilhelm-Pieck-University Rostock, GDR.
Biomaterials, Artificial Cells, and Artificial Organs
|January 1, 1990
Summary
Symplex capsules offer technical suitability for extracorporeal detoxification due to their partial permeability and mechanical strength. A new procedure significantly enhances encapsulated enzyme activity, making this application advisable for improved detoxification.
Area of Science:
- Biotechnology
- Biomedical Engineering
- Biochemistry
Background:
- Symplex capsules possess desirable mechanical properties and partial permeability.
- Extracorporeal detoxification requires efficient and stable enzyme systems.
Purpose of the Study:
- To evaluate the suitability of symplex capsules for extracorporeal detoxification.
- To assess the impact of a novel procedure on encapsulated enzyme activity.
Main Methods:
- Characterization of symplex capsule properties (permeability, mechanical strength).
- Development and application of a new procedure to enhance enzyme activity within capsules.
- Assessment of enzyme activity in the context of extracorporeal detoxification.
Main Results:
- Symplex capsules demonstrate technical suitability for extracorporeal detoxification applications.
- The newly developed procedure leads to a considerable increase in encapsulated enzyme activity.
Conclusions:
- The enhanced enzyme activity within symplex capsules supports their advisability for extracorporeal detoxification.
- This approach presents a promising advancement in detoxification technologies.