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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
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Cellular growth factors in relation to mortality from cardiovascular disease in middle-aged Japanese: the JACC study

Hiroyasu Iso1, Koutatsu Maruyama, Satoyo Ikehara

  • 1Public Health, Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine, Japan. iso@pbhel.med.osaka-u.ac.jp

Atherosclerosis
|August 4, 2012
PubMed

Insights

Insulin-like growth factor I (IGF-I) was linked to lower intraparenchymal hemorrhage risk, while transforming growth factor beta 1 (TGF-β1) was associated with reduced ischemic stroke mortality. These findings suggest cellular growth factors may influence stroke development.

Area of Science:

  • Cardiovascular Epidemiology
  • Biomarkers in Disease
  • Cellular Biology and Disease Mechanisms

Background:

  • Limited population-based data exists on cellular growth factors and cardiovascular disease.
  • Cellular growth factors play roles in cell proliferation and tissue repair, potentially impacting cardiovascular health.

Purpose of the Study:

  • To investigate the association between specific cellular growth factors and mortality from stroke and coronary heart disease.
  • To explore the potential role of cellular proliferation in cardiovascular disease outcomes.

Main Methods:

  • A nested case-control study within the JACC prospective cohort (39,242 participants aged 40-79).
  • Measurement of serum insulin-like growth factors I, II (IGF-I, IGF-II), binding protein-3 (IGFBP-3), and transforming growth factor beta 1 (TGF-β1).
  • Matching of cases and controls for sex, age, residence, and serum storage year.

Main Results:

  • A 9-year follow-up identified 233 stroke deaths and 97 coronary heart disease deaths.
  • Higher IGF-I levels showed an inverse association with intraparenchymal hemorrhage mortality (OR 0.31; 95% CI 0.14-0.71).
  • Higher TGF-β1 levels were inversely associated with ischemic stroke mortality (OR 0.58; 95% CI 0.34-0.98).
  • IGF-II and IGFBP-3 were not significantly associated with any studied mortality outcomes.

Conclusions:

  • IGF-I is inversely associated with intraparenchymal hemorrhage mortality.
  • TGF-β1 is inversely associated with ischemic stroke mortality.
  • These findings suggest a role for cellular proliferation in stroke pathogenesis or prognosis.
Abstract

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