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Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

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Changes in regional brain volume three months after stroke.

Amy Brodtmann¹, Heath Pardoe, Qi Li

¹Florey Neuroscience Institutes, Melbourne Brain Centre, 245 Burgundy Street, Heidelberg, 3081, Australia. agbrod@unimelb.edu.au

Journal of the Neurological Sciences

|August 4, 2012

Summary

Stroke can cause brain changes within months. Some brain regions show increased thickness, while thalamic volume decreases, suggesting compensatory mechanisms and early atrophy after stroke.

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Area of Science:

Neuroscience
Neurology
Radiology

Background:

Understanding regional brain volume changes post-stroke is limited.
This study investigates cortical thickness and brain volume alterations over three months following stroke.

Purpose of the Study:

To examine changes in regional cortical thickness and brain volumes (hippocampus, thalamus) in stroke patients compared to controls over three months.
To identify potential compensatory mechanisms and early signs of atrophy after stroke.

Main Methods:

Longitudinal study of acute hemispheric stroke patients and controls using high-resolution T1 MRI scans.
Analysis of cortical thickness, hippocampal, and thalamic volumes using FreeSurfer V5.0.
Comparison of brain volumes at stroke onset and three months, with paired sample t-tests for significance.

Main Results:

No significant changes in brain volumes were observed in control subjects over three months.
Stroke patients exhibited increased cortical thickness in contralesional regions (paracentral, superior frontal, insula).
A significant reduction in thalamic volume was observed, particularly in ipsilesional areas.

Conclusions:

Regional cortical thickness changes are detectable within months after stroke.
Contralesional cortical thickening may indicate compensatory brain activity.
Thalamic volume reduction suggests early post-stroke atrophy, warranting further investigation.