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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

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Related Experiment Video

Updated: May 19, 2026

Trophoblast Cell Recovery from Angiogenesis-Tube Formation Assay for Differentiation Marker Expression Analysis
05:30

Trophoblast Cell Recovery from Angiogenesis-Tube Formation Assay for Differentiation Marker Expression Analysis

Published on: November 8, 2024

Notch signaling pathway and human placenta.

Wei-Xiu Zhao1, Jian-Hua Lin

  • 1Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

International Journal of Medical Sciences
|August 4, 2012
PubMed
Summary

Notch signaling is vital for placental development. This review explores Notch receptors and ligands in human placental trophoblast function and angiogenesis, offering insights into pregnancy disorders.

Keywords:
Notch pathwayhumanplacentapreeclampsia.

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In Vitro Differentiation of Human Pluripotent Stem Cells into Trophoblastic Cells
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In Vitro Differentiation of Human Pluripotent Stem Cells into Trophoblastic Cells

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Last Updated: May 19, 2026

Trophoblast Cell Recovery from Angiogenesis-Tube Formation Assay for Differentiation Marker Expression Analysis
05:30

Trophoblast Cell Recovery from Angiogenesis-Tube Formation Assay for Differentiation Marker Expression Analysis

Published on: November 8, 2024

In Vitro Differentiation of Human Pluripotent Stem Cells into Trophoblastic Cells
08:21

In Vitro Differentiation of Human Pluripotent Stem Cells into Trophoblastic Cells

Published on: March 16, 2017

Area of Science:

  • Developmental Biology
  • Cell Signaling
  • Reproductive Medicine

Background:

  • Notch signaling is evolutionarily conserved and crucial for cell fate determination and differentiation.
  • Evidence indicates the Notch signaling pathway is important in mammalian placental development.
  • While most Notch family proteins are found in the human placenta, Delta-like 3's role is unclear, and regulatory mechanisms remain largely unknown.

Purpose of the Study:

  • To investigate the expression patterns of Notch family members in the human placenta.
  • To elucidate the mechanisms regulating Notch signaling activation in human placental development.
  • To review the roles of Notch receptors and ligands in human placental trophoblast function and angiogenesis.

Main Methods:

  • Literature review focusing on Notch signaling in human placentation.
  • Analysis of existing research on Notch receptors and ligands.
  • Synthesis of data regarding trophoblast function and placental angiogenesis.

Main Results:

  • Notch signaling pathways are implicated in key placental processes.
  • Specific Notch receptors and ligands play roles in trophoblast function.
  • Notch signaling influences placental angiogenesis.

Conclusions:

  • Understanding Notch signaling in the human placenta is critical for elucidating its role in normal placentation.
  • Further research can provide perspectives on pregnancy complications like preeclampsia.
  • This review highlights the need for continued investigation into Notch pathway regulation and function in the placenta.