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Related Concept Videos

Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Urinary Tract Calculi III: Medical Management01:30

Urinary Tract Calculi III: Medical Management

The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
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Pharmacological management
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Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

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COPD: Pathogenesis and Clinical Features

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Related Experiment Video

Updated: May 19, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Gout: why is this curable disease so seldom cured?

Michael Doherty1, Tim L Jansen, George Nuki

  • 1Department of Rheumatology, City Hospital, Nottingham, UK. Michael.Doherty@nottingham.ac.uk

Annals of the Rheumatic Diseases
|August 7, 2012
PubMed
Summary

Gout, a common inflammatory arthritis, is often undertreated due to negative perceptions and inadequate patient/provider education. Improving understanding and treatment of this curable crystal deposition disease is crucial for better patient outcomes.

Related Experiment Videos

Last Updated: May 19, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Area of Science:

  • Rheumatology
  • Crystal-induced arthritis

Background:

  • Gout is the most prevalent inflammatory arthritis, with well-understood pathogenesis and risk factors.
  • Current guidelines aim for gout 'cure', yet audits reveal suboptimal patient care and outcomes.
  • Negative historical perceptions portray gout as self-inflicted and benign, hindering effective management.

Purpose of the Study:

  • To highlight the gap between gout treatment objectives and current clinical practice.
  • To address the impact of negative disease perceptions on patient and provider management strategies.
  • To emphasize the need for improved education and treatment of gout as a chronic crystal deposition disease.

Main Methods:

  • Review of current gout management guidelines and audit data.
  • Analysis of historical and contemporary perceptions of gout.
  • Evaluation of urate-lowering treatment prescription and dosage patterns.

Main Results:

  • A minority of gout patients receive adequate advice and treatment.
  • Urate-lowering therapies are frequently underprescribed and underdosed.
  • Misconceptions about gout contribute to suboptimal care, focusing on acute attacks over chronic disease management.

Conclusions:

  • Gout is an easily diagnosed, curable, yet often severe inflammatory arthritis.
  • Overcoming negative perceptions and improving patient/provider education are key to enhancing gout management.
  • Recent advancements in urate-lowering treatments offer an opportunity to improve care for this chronic crystal deposition disease.