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Updated: May 19, 2026

Natural Killer (NK) and CAR-NK Cell Expansion Method using Membrane Bound-IL-21-Modified B Cell Line
Published on: February 8, 2022
When NK cells overcome their lack of education
Baptiste N Jaeger1, Eric Vivier
1Centre d’Immunologie de Marseille-Luminy, Aix-Marseille Université UM2, Campus de Luminy case 906, Assistance Publique—Hôpitaux de Marseille, Hôpital de la Conception, Marseille, France.
Abstract:
Cells of the immune system have evolved various molecular mechanisms to sense their environment and react to alterations of self. NK cells are lymphocytes with effector and regulatory functions, which are remarkably adaptable to changes in self. In a study published in this issue of the JCI, Tarek and colleagues report the clinical benefits of manipulating NK cell adaptation to self in an innovative mAb-based therapy against neuroblastoma (NB). This novel therapeutic strategy should stimulate further research on NK cell therapies.
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