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Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid

Tong-Fei Liu1, Jing-Jie Tang, Pei-Shan Li

  • 1The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China.

Cell Metabolism
|August 7, 2012
PubMed
Summary

Deleting gp78 (a ubiquitin ligase) in the liver reduces lipid biosynthesis and improves metabolic health. This leads to decreased obesity and glucose intolerance, offering potential benefits for metabolic diseases.

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