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Related Experiment Videos

Diurnal variations in lung transfer factor and its components.

K K Mahajan1, S K Mahajan, N Mishra

  • 1Department of Physiology, Medical College & Hospital, Rohtak, Haryana.

Indian Journal of Physiology and Pharmacology
|July 1, 1990
PubMed
Summary

Lung function tests, including transfer factor (Tlco) and vital capacity (VC), show daily variations in healthy adults. These diurnal changes are minor, suggesting consistent testing times, preferably mornings, for reliable results.

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Area of Science:

  • Pulmonary Physiology
  • Respiratory Medicine
  • Lung Function Testing

Background:

  • Understanding diurnal variations in lung function is crucial for accurate clinical assessment.
  • Previous research indicates potential daily fluctuations in respiratory parameters.

Purpose of the Study:

  • To investigate serial changes in lung transfer factor and its components throughout the day.
  • To assess the impact of airway patency on lung diffusion function.
  • To determine the clinical significance of diurnal variations in pulmonary function tests.

Main Methods:

  • Serial measurements of lung transfer factor (Tlco), its components (e.g., VA), forced vital capacity (FVC), and forced expiratory flow (EFR25-75%) were performed thrice daily.
  • Study involved 20 healthy, non-smoking adult males.

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  • Data analysis focused on identifying statistically significant changes and correlations.

    • Main Results:

    • All measured lung transfer components exhibited a decrease as the day progressed.
    • Statistically significant reductions were observed for Tlco and VA.
    • Decreases in FVC and EFR25-75% correlated with diffusion function changes, suggesting airway patency influences lung diffusion.
    • Daily variations were generally less than 7.4%.

    Conclusions:

    • Diurnal variations in lung function, particularly Tlco and VA, are present in healthy adults.
    • Airway patency appears to influence lung diffusion capacity.
    • While minor, these variations necessitate standardized testing times, ideally in the morning when values are maximal, to ensure diagnostic reliability.