Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cholera01:25

Cholera

Cholera is an acute gastrointestinal disease caused by the Gram-negative bacterium Vibrio cholerae. It is transmitted primarily via the fecal-oral route through the ingestion of contaminated water or food.Vibrio cholerae is a motile, Gram-negative bacterium of the family Vibrionaceae, primarily associated with waterborne outbreaks in areas with inadequate sanitation. Although over 200 serogroups of V. cholerae exist, only O1 and O139 are responsible for epidemic cholera. The O1 serogroup,...
Immunological Memory01:23

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...
Reservoir of Infection01:30

Reservoir of Infection

Infectious diseases arise from intricate interactions between pathogens and their reservoirs. A reservoir of infection refers to the natural habitat where a pathogen lives, grows, and multiplies, serving as a continual source of infection. Reservoirs are broadly classified as either living or nonliving, and each plays a unique role in disease transmission, significantly influencing public health interventions and control strategies.Humans act as reservoirs for a wide array of pathogens,...
Vaccinations01:51

Vaccinations

Overview
Stages of Infection01:26

Stages of Infection

Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimal Harvesting in Stream Networks: Maximizing Biomass and Yield.

Bulletin of mathematical biology·2026
Same author

Retrospective analysis of age-specific non-pharmaceutical interventions on wild-type SARS-CoV-2 in Canada.

BMC public health·2026
Same author

Estimation of the exponential growth rate of an epidemic.

Infectious Disease Modelling·2026
Same author

A New Perspective on Determining Disease Invasion and Population Persistence in Heterogeneous Environments.

Journal of mathematical biology·2025
Same author

Distributions of prevalence and daily new cases in a stochastic linear SEIR model.

Mathematical biosciences·2025
Same author

Estimating the effect of contact tracing during the early stage of an epidemic.

Infectious Disease Modelling·2025
Same journal

Slow Evolution Towards Generalism in a Model of Variable Dietary Range.

Bulletin of mathematical biology·2026
Same journal

CBINN: Cancer Biology-Informed Neural Network for Unknown Parameter Estimation and Missing Physics Identification.

Bulletin of mathematical biology·2026
Same journal

A Cost-Sensitive Behavioral Modeling Analysis of the Early Identification and Control of Infectious Diseases.

Bulletin of mathematical biology·2026
Same journal

Tracking Dynamics of Superspreading Through Contacts, Exposures, and Transmissions in Edge-Based Network Epidemics.

Bulletin of mathematical biology·2026
Same journal

The Exact Hypergeometric Posterior Method for Accurate Inference of Population Size from Mark-Recapture Data.

Bulletin of mathematical biology·2026
Same journal

Modeling, Analysis, and Optimal Control of Leukemic Cell Population Dynamics Under Therapy.

Bulletin of mathematical biology·2026
See all related articles

Related Experiment Video

Updated: May 19, 2026

Quantifying Vibrio cholerae Colonization and Diarrhea in the Adult Zebrafish Model
08:03

Quantifying Vibrio cholerae Colonization and Diarrhea in the Adult Zebrafish Model

Published on: July 12, 2018

Cholera models with hyperinfectivity and temporary immunity.

Zhisheng Shuai1, Joseph H Tien, P van den Driessche

  • 1Department of Mathematics and Statistics, University of Victoria, BC, Canada. zshuai@uvic.ca

Bulletin of Mathematical Biology
|August 7, 2012
PubMed
Summary
This summary is machine-generated.

This study models cholera, revealing that hyperinfectivity and temporary immunity can cause disease oscillations. The basic reproduction number (R0) predicts if cholera will persist or die out, with R0 > 1 leading to endemic disease.

More Related Videos

Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages
09:39

Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages

Published on: May 30, 2013

Vibrio cholerae: Model Organism to Study Bacterial Pathogenesis - Interview
06:44

Vibrio cholerae: Model Organism to Study Bacterial Pathogenesis - Interview

Published on: May 28, 2007

Related Experiment Videos

Last Updated: May 19, 2026

Quantifying Vibrio cholerae Colonization and Diarrhea in the Adult Zebrafish Model
08:03

Quantifying Vibrio cholerae Colonization and Diarrhea in the Adult Zebrafish Model

Published on: July 12, 2018

Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages
09:39

Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages

Published on: May 30, 2013

Vibrio cholerae: Model Organism to Study Bacterial Pathogenesis - Interview
06:44

Vibrio cholerae: Model Organism to Study Bacterial Pathogenesis - Interview

Published on: May 28, 2007

Area of Science:

  • Epidemiology
  • Mathematical Biology
  • Infectious Disease Modeling

Background:

  • Cholera remains a significant global health threat.
  • Understanding disease dynamics is crucial for effective control strategies.
  • Existing models may not fully capture complex factors like hyperinfectivity and temporary immunity.

Purpose of the Study:

  • To develop a mathematical model for cholera transmission.
  • To investigate the impact of hyperinfectivity and temporary immunity on disease dynamics.
  • To analyze the conditions leading to cholera oscillations and endemicity.

Main Methods:

  • Formulation of a mathematical model incorporating distributed delays for hyperinfectivity and temporary immunity.
  • Definition and analysis of the basic reproduction number (R0) as a threshold parameter.
  • Numerical simulations to explore model behavior under different parameter values and infectivity kernels.
  • Quantitative analysis of cholera data from existing literature.

Main Results:

  • The basic reproduction number (R0) was defined and validated as a sharp threshold for cholera extinction or persistence.
  • When R0 > 1, the endemic equilibrium can become unstable, leading to disease oscillations.
  • Numerical simulations demonstrated the quantitative influence of hyperinfectivity and temporary immunity on oscillation patterns.

Conclusions:

  • Hyperinfectivity and temporary immunity are critical factors influencing cholera's epidemiological dynamics.
  • The model provides insights into the mechanisms driving cholera outbreaks and oscillations.
  • Mathematical modeling, incorporating realistic biological factors, is essential for predicting and managing infectious diseases.