Atropine sulphate: rescue therapy for pyloric stenosis

Richard Peter Owen1, Sarah L Almond, Gill M E Humphrey

  • 1Department of General Surgery, Arrowe Park Hospital, Liverpool, UK. richowen83@hotmail.com

BMJ Case Reports
|August 7, 2012
PubMed

Insights

Infantile hypertrophic pyloric stenosis (IHPS) can be complicated by incomplete surgery. This case study shows successful non-surgical management of IHPS with incomplete pyloromyotomy using atropine sulfate therapy.

Area of Science:

  • Pediatric Surgery
  • Gastroenterology

Background:

  • Infantile hypertrophic pyloric stenosis (IHPS) causes gastric outlet obstruction, treated surgically with pyloromyotomy.
  • Incomplete pyloromyotomy occurs in 0.3% of cases, requiring reoperation.
  • Medical management with antimuscarinics is an alternative but often requires prolonged hospitalization.

Purpose of the Study:

  • To describe a case of IHPS with incomplete pyloromyotomy.
  • To highlight the successful medical management of this complication.

Main Methods:

  • A case of IHPS with incomplete pyloromyotomy was identified.
  • The patient was treated with atropine sulfate therapy.

Main Results:

  • Successful management of IHPS following incomplete pyloromyotomy was achieved with atropine sulfate.
  • This approach avoided further surgical intervention.

Conclusions:

  • Atropine sulfate therapy is a viable treatment option for IHPS cases complicated by incomplete pyloromyotomy.
  • Medical management can offer a less invasive alternative to repeat surgery.

Related Concept Videos

Pyloric Obstruction01:11

Pyloric Obstruction

Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...
Anticholinesterase Agents: Poisoning and Treatment01:26

Anticholinesterase Agents: Poisoning and Treatment

Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

Cardiopulmonary Resuscitation IV: Pharmacological Management

Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
Peptic Ulcer Disease V: Surgical Management and Nursing Care01:25

Peptic Ulcer Disease V: Surgical Management and Nursing Care

Surgical management and nursing care are crucial in treating Peptic Ulcer Disease (PUD). Here is an organized and enhanced overview of the surgical interventions and the associated nursing care for PUD:
Surgical Interventions for Peptic Ulcer Disease
Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current medication...
Adrenergic Agonists: Therapeutic Uses01:30

Adrenergic Agonists: Therapeutic Uses

Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and anaphylaxis:...