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Updated: May 19, 2026

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
Published on: October 5, 2015
Cytokine-secreting activity of blood eosinophils in pulmonary tuberculosis
U V Kolobovnikova1, O I Urazova, V V Novitsky
1Department of Pathophysiology, Siberian State Medical University, Federal Agency for Health and Social Development, Tomsk, Russia. kolobovnikova.julia@mail.ru
Abstract:
Modern immunological studies showed that eosinophilic granulocytes producing the key mediators of cellular and humoral immune response contribute to the common cytokine imbalance developing in tuberculous infection. A significant increase in BCG-induced secretion of IL-2, IL-5, and TNF-α by eosinophils in patients with pulmonary tuberculosis indicated high reserve reactivity of eosinophilic cells realizing their functional potential in regulation of the specific resistance reactions of the microorganism under conditions of M. tuberculosis infection.
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