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Single-dose pharmacokinetics of fluphenazine after fluphenazine decanoate administration
G M Simpson1, K G Yadalam, D F Levinson
1Department of Psychiatry, Medical College of Pennsylvania, Eastern Pennsylvania Psychiatric Institute, Philadelphia 19129.
Journal of Clinical Psychopharmacology
|December 1, 1990
Abstract:
Fluphenazine decanoate is commonly used as part of maintenance treatment of schizophrenia, but its pharmacokinetics are poorly understood. We administered a single intramuscular dose of fluphenazine decanoate to nine patients and found that plasma fluphenazine level did not decline to 50% of the peak level by day 26 in any of the patients. This means that it has a long half-life measurable in months rather than weeks.