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Related Concept Videos

Therapeutic Drug Monitoring: Drug Analysis Methods01:26

Therapeutic Drug Monitoring: Drug Analysis Methods

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...
Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence01:19

Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence

Pharmaceutical products contain more than just the active drug; they also contain various excipients such as binders, solubilizers, stabilizers, preservatives, and other elements. In some cases, impurities or contaminants might be present. Traditionally, quality control in pharmaceuticals has primarily focused on the analysis of the active drug, often overlooking the impact of these additional components. The recent issue with heparin contamination by over-sulfated chondroitin sulfate, a...
Drug Concentrations: Measurements01:23

Drug Concentrations: Measurements

Drug concentration is the quantity of a drug present in a biological sample. Measuring drug amounts in biological samples allows the clinician to understand how a drug is absorbed, distributed, metabolized, and excreted. Samples can be obtained through invasive or non-invasive methods. Invasive techniques involve surgical or parenteral interventions to gather blood, cerebrospinal fluid, or tissue biopsy. Conversely, non-invasive approaches provide samples like urine, feces, and saliva.
Plasma —...
Clinically Relevant Drug Product Specifications: Methods of Establishment01:29

Clinically Relevant Drug Product Specifications: Methods of Establishment

Product specifications define the acceptable quality of a pharmaceutical product by ensuring identity, purity, potency, and strength. These specifications serve as benchmarks during development, manufacturing, and post-approval quality control. Clinically relevant specifications are particularly important because they directly relate to a drug's safety and efficacy in clinical use.Dissolution studies are critical biopharmaceutic tools that link in vitro behavior to in vivo performance. They...
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
MALDI-TOF Mass Spectrometry01:19

MALDI-TOF Mass Spectrometry

Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.Matrix-assisted laser desorption ionization (MALDI) is a commonly...

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Updated: May 19, 2026

Identification of Pharmaceuticals in The Aquatic Environment Using HPLC-ESI-Q-TOF-MS and Elimination of Erythromycin Through Photo-Induced Degradation
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Identification of Pharmaceuticals in The Aquatic Environment Using HPLC-ESI-Q-TOF-MS and Elimination of Erythromycin Through Photo-Induced Degradation

Published on: August 1, 2018

New insights in pharmaceutical analysis.

Davy Guillarme1, Julie Schappler, Julien Boccard

  • 1Research Unit of Pharmaceutical Analytical Chemistry, School of Pharmaceutical Sciences, Geneva-Lausanne, University of Geneva, 20 bd d'Yvoy CH-1211 Geneva 4, Switzerland.

Chimia
|August 8, 2012
PubMed
Summary

Pharmaceutical analytical chemistry research focuses on advanced separation techniques like liquid chromatography (LC) and capillary electrophoresis (CE). Chemometric approaches are applied to optimize methods and analyze complex data for improved results.

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Last Updated: May 19, 2026

Identification of Pharmaceuticals in The Aquatic Environment Using HPLC-ESI-Q-TOF-MS and Elimination of Erythromycin Through Photo-Induced Degradation
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High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

Area of Science:

  • Pharmaceutical Analytical Chemistry
  • Separation Science

Background:

  • The Pharmaceutical Analytical Chemistry (PAC) research unit has extensive experience in separation sciences.
  • Key techniques studied include liquid chromatography (LC), ultra-high performance chromatography (UHPLC), supercritical fluid chromatography (SFC), and capillary electrophoresis (CE).
  • These methods are investigated for their fundamental principles and diverse application capabilities, particularly for macromolecules and cost-effective analyses.

Purpose of the Study:

  • To thoroughly investigate advanced separation techniques and their application capabilities.
  • To address the challenge of extracting relevant information from large datasets generated by modern analytical platforms.
  • To implement statistical and mathematical methodologies for optimizing analytical processes and data analysis.

Main Methods:

  • Advanced separation techniques: LC, UHPLC, SFC, and CE.
  • Detection methods including Mass Spectrometry (MS) for high sensitivity and selectivity.
  • Chemometric approaches: Design of Experiments (DoE) and Multivariate Data Analysis (MVDA).

Main Results:

  • Demonstrated the utility of statistical and mathematical methodologies in enhancing result quality.
  • Optimized analytical processes from method development to data analysis using chemometrics.
  • Successfully applied various separation and detection techniques for diverse applications requiring high sensitivity and selectivity.

Conclusions:

  • Advanced separation techniques combined with chemometric approaches are crucial for efficient data analysis and knowledge discovery.
  • The PAC research unit's expertise in separation science and data analysis provides valuable insights.
  • Implementing robust analytical methodologies ensures high-quality results in pharmaceutical analysis.