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Aflibercept in pediatric solid tumors: moving beyond the trap

Cindy H Chau1, William D Figg

  • 1Molecular Pharmacology Section, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|August 8, 2012
PubMed

Insights

Angiogenesis inhibitors show promise for childhood cancers, with aflibercept offering a proof-of-principle. Further research is needed to establish effective clinical endpoints and biomarkers for pediatric trials.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Angiogenesis is crucial for solid tumor growth and metastasis in both adults and children.
  • Targeting angiogenesis is a key strategy in cancer therapy.

Purpose of the Study:

  • To review the role of angiogenesis inhibitors in pediatric oncology.
  • To highlight the potential and challenges of developing these therapies for childhood cancers.

Main Methods:

  • Review of current clinical investigations and pediatric trials of angiogenesis inhibitors.
  • Analysis of the proof-of-principle study involving aflibercept in pediatric patients.

Main Results:

  • Clinical trials investigating angiogenesis inhibitors for pediatric solid tumors are ongoing.
  • The pediatric study of aflibercept demonstrates the feasibility of targeting angiogenesis in children.

Conclusions:

  • While promising, developing effective clinical endpoints and reliable biomarkers for angiogenesis inhibition in pediatric trials remains a significant challenge.
  • Further research is essential to optimize the use of angiogenesis inhibitors in treating childhood cancers.

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