Related Experiment Video
Updated: May 19, 2026
09:24
Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells
Published on: August 12, 2015
Hidden dangers: a cryptic exon disrupts BRCA2 mRNA
James D Fackenthal1, Younghee Lee, Olufunmilayo I Olopade
1Center for Clinical Cancer Genetics and Global Health, The University of Chicago Medical Center, Chicago, IL 60637, USA.
Abstract:
The first mutation that disrupts BRCA2 mRNA by including a novel, cryptic exon is reported in this issue. The mutation lies deep within an intron and would not have been detected by conventional screening methods. In the future, more mutations may be discovered by direct mRNA analysis.
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