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Related Experiment Video

Updated: May 19, 2026

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function
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Movement kinematic after deep brain stimulation associated microlesions.

Arun Singh1, Stefan Kammermeier, Jan Hinnerk Mehrkens

  • 1Department of Neurology, Klinikum Großhadern, Ludwig-Maximilian University, Marchioninistr. 15, 81377 Munich, Germany.

Journal of Neurology, Neurosurgery, and Psychiatry
|August 8, 2012
PubMed
Summary

Deep brain stimulation (DBS) offers immediate symptom relief for movement disorders. Post-implantation, Parkinson

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Area of Science:

  • Neurosurgery
  • Neurology
  • Movement Disorders

Background:

  • Deep brain stimulation (DBS) is a key treatment for Parkinson's disease and dystonia.
  • Immediate clinical symptom improvement is observed post-DBS electrode implantation.
  • The impact of the 'microlesion effect' on movement kinematics remains unclear.

Purpose of the Study:

  • To investigate the effects of DBS electrode implantation on movement kinematics.
  • To differentiate the kinematic changes in Parkinson's disease versus dystonia patients post-implantation.

Main Methods:

  • Studied arm, hand, and finger movements in Parkinson's disease and dystonia patients.
  • Compared preoperative movements with immediate postoperative movements after DBS electrode implantation.

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  • Assessed kinematic changes without active stimulation to isolate the microlesion effect.

    • Main Results:

    • A significant reduction in clinical symptoms was observed in both patient groups post-implantation, without stimulation.
    • Parkinson's disease patients exhibited increased movement velocity postoperatively.
    • Dystonia patients demonstrated significantly slower movement velocity after electrode implantation.

    Conclusions:

    • Both lesioning and stimulation of targeted brain structures yield similar clinical benefits.
    • Globus pallidus internus lesions may act by inhibiting systems controlling muscle tone and posture.
    • Subthalamic nucleus stimulation or lesioning appears to cause a more general disinhibition of movement.