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Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

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Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

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Drug Toxicity: Risk factors01:24

Drug Toxicity: Risk factors

Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
Skin Cancer01:30

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Related Experiment Video

Updated: May 19, 2026

Venous Thrombosis Assay in a Mouse Model of Cancer
04:40

Venous Thrombosis Assay in a Mouse Model of Cancer

Published on: January 5, 2024

Malignancy risk in vasculitis.

Tanaz A Kermani1, Kenneth J Warrington, Shreyasee Amin

  • 1Division of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.

Therapeutic Advances in Musculoskeletal Disease
|August 8, 2012
PubMed
Summary
This summary is machine-generated.

Patients with certain autoimmune vasculitides may face increased cancer risk. Some vasculitis forms can also be a sign of underlying malignancy, highlighting a complex relationship.

Keywords:
cancercyclophosphamidemalignancyparaneoplasticvasculitis

Related Experiment Videos

Last Updated: May 19, 2026

Venous Thrombosis Assay in a Mouse Model of Cancer
04:40

Venous Thrombosis Assay in a Mouse Model of Cancer

Published on: January 5, 2024

Area of Science:

  • Rheumatology
  • Oncology
  • Immunology

Background:

  • Vasculitides are rare autoimmune diseases with complex associations.
  • Concurrent malignancies are reported in some vasculitis patients.
  • Vasculitis can be a paraneoplastic phenomenon or indicate cancer risk.

Purpose of the Study:

  • To review cancer risk in patients with specific vasculitides.
  • To discuss vasculitis as a paraneoplastic manifestation.
  • To highlight the interplay between vasculitis and malignancy.

Main Methods:

  • Literature review of cancer risk in vasculitis.
  • Focus on large vessel vasculitis (GCA, Takayasu arteritis).
  • Review of polyarteritis nodosa and ANCA-associated vasculitides.
  • Discussion of vasculitis as a paraneoplastic phenomenon.
  • Examination of cutaneous vasculitis as a cancer manifestation.

Main Results:

  • Patients with certain vasculitides may have elevated cancer risk.
  • Vasculitis can manifest as a paraneoplastic syndrome.
  • Polyarteritis nodosa associated with hairy cell leukemia is a key example.
  • Cutaneous vasculitis is a common vasculitic manifestation of cancer.

Conclusions:

  • A significant association exists between vasculitis and malignancy.
  • Understanding this link is crucial for patient management.
  • Further research into shared mechanisms is warranted.