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Familial predisposition to vasovagal syncope.
Marta Negrusz-Kawecka1, Tomasz Bańkowski, Mateusz Tabin
1Department of Cardiology, Wroclaw Medical University, Poland.
Acta Cardiologica
|August 9, 2012
Summary
Vasovagal syncope (WS) is more common in women. A family history of syncope, particularly in fathers, increases the risk for both men and women, suggesting a genetic link.
Area of Science:
- Cardiology
- Genetics
- Epidemiology
Background:
- Vasovagal syncope (WS) has a suggested familial predisposition, but existing data are limited.
- Understanding the familial occurrence of WS is crucial for identifying potential genetic factors.
Purpose of the Study:
- To determine the prevalence of vasovagal syncope in young adults.
- To investigate the familial occurrence and inheritance patterns of vasovagal syncope.
Main Methods:
- A questionnaire assessing syncopal history was administered to 392 young adults (18-32 years).
- Prevalence of syncope was analyzed in participants and their immediate family members (mothers, fathers, sisters, brothers).
- Logistic regression analysis identified factors associated with a positive syncope history.
Main Results:
- Syncope was reported in 32.1% of the studied young adults (36.7% of women, 20.7% of men).
- Positive family history for syncope was observed in 29.1% of mothers, 16.8% of fathers, 30.9% of sisters, and 14.2% of brothers.
- Female gender (OR 2.17), maternal syncope history (OR 1.74), and paternal syncope history (OR 2.22) were significantly associated with syncope in the studied group.
Conclusions:
- A family history of syncope in male relatives increases risk for both genders, while in female relatives, it increases risk only in women.
- Female gender is an independent risk factor for vasovagal syncope.
- The genetics of vasovagal syncope may be polygenic, but transmission mechanisms require further investigation.
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