Related Experiment Video
Updated: May 19, 2026

Characterizing Modulators of Protease-Activated Receptors with a Calcium Mobilization Assay Using a Plate Reader
Published on: May 24, 2024
First-in-class antifibrotic therapy targeting type 1 lysophosphatidic acid receptor
1College of Pharmacy (BK21 Project) and Longevity Institute of Life Science and Technology, Pusan National University, Busan 609-735, Korea. imds@pusan.ac.kr
Abstract:
Fibrosis is a normal process for repairing injured tissue. However, aberrant or hyperfibrotic responses result in serious pathologic conditions and sometimes life-threatening diseases. A new class of drugs antagonizing type 1 lysophosphatidic acid receptor has been developed and is under investigation in clinical trials for the treatment of idiopathic pulmonary fibrosis and systemic fibrosis or scleroderma. This will be the first drug in its class to target G-protein-coupled receptors for lysophosphatidic acid.
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