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Updated: May 19, 2026

Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry
Published on: February 4, 2017
Radiometals from liquid targets: 94mTc production using a standard water target on a 13 MeV cyclotron
Cornelia Hoehr1, Tom Morley, Ken Buckley
1TRIUMF, 4004 Wesbrook Mall, Vancouver, BC, Canada. choehr@triumf.ca
Abstract:
Solutions containing a high concentration (0.325-0.995 g/ml) of natural-abundance ammonium heptamolybdate tetrahydrate ((NH(4))(6)Mo(7)O(24))·4H(2)O were irradiated at 13 MeV on a proton-beam cyclotron using a standard liquid target. (94m)Tc was produced via the (94)Mo(p,n)(94m)Tc reaction with measured yields of 110±20 MBq for the highest concentrated solution using 5 μA proton beams for 60 min. Saturation yields of up to 40±6 MBq/μA were achieved. Pertechnetate was isolated from the target mixture with 70.9±0.7% efficiency using a solid-phase extraction resin.
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