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Related Experiment Video

Updated: May 19, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Preventing bone complications in prostate cancer.

Mohamed Bishr¹, Fred Saad

¹Centre de recherche du Centre hospitalier de l'Université de Montréal and Institut du cancer de Montréal, Montreal, Quebec, Canada.

Current Opinion in Supportive and Palliative Care

|August 9, 2012

Summary

Prostate cancer patients face skeletal morbidities. Osteoclast-targeted therapies like denosumab and zoledronic acid effectively reduce skeletal-related events and fractures in high-risk patients.

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Area of Science:

Oncology
Bone Metabolism
Prostate Cancer Research

Background:

Prostate cancer (PCa) patients are at high risk for skeletal morbidities due to bone metastases and androgen deprivation therapy (ADT)-related bone loss.
Skeletal morbidities, including pain, fractures, and spinal cord compression, significantly reduce quality of life and increase healthcare costs.

Purpose of the Study:

To review management options for reducing skeletal morbidity in prostate cancer patients.
To highlight effective therapies for preventing skeletal-related events.

Main Methods:

Review of current literature on managing skeletal complications in prostate cancer.
Analysis of evidence supporting various therapeutic interventions.

Main Results:

Osteoclast-targeted therapies, including denosumab and zoledronic acid, demonstrate strong evidence for efficacy.
These therapies are FDA-approved for reducing skeletal-related events in castration-resistant prostate cancer and preventing fractures in high-risk patients.

Conclusions:

Osteoclast-targeted therapy is a key strategy for managing skeletal morbidity in prostate cancer.
Ongoing research is exploring the broader application of these therapies across different disease stages.