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Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1) level in hemodialysis patients and parameters affecting

Sukru Ulusoy1, Gulsum Ozkan, Ahmet Menteşe

  • 1Department of Nephrology, Karadeniz Technical University, School of Medicine, Turkey. sulusoy2002@yahoo.com

Clinical Biochemistry
|August 10, 2012
PubMed

Insights

Signal peptide-CUB (SCUBE1) protein levels are elevated in hemodialysis patients, even without acute ischemia. Various factors related to dialysis and patient health influence these SCUBE1 levels.

Area of Science:

  • Biochemistry
  • Nephrology
  • Hematology

Background:

  • SCUBE1 is a cell surface protein associated with platelet activation in acute ischemic events.
  • Hemodialysis patients exhibit impaired platelet function and activation.
  • SCUBE1 levels have not been previously studied in hemodialysis patients.

Purpose of the Study:

  • To investigate SCUBE1 levels in hemodialysis patients.
  • To identify factors influencing SCUBE1 levels in this population.

Main Methods:

  • Included 103 hemodialysis patients and 21 healthy controls.
  • Measured SCUBE1 and sCD40L levels pre- and post-hemodialysis.
  • Correlated SCUBE1 with sCD40L, demographics, dialysis parameters, and biochemical tests.

Main Results:

  • SCUBE1 levels were significantly higher in hemodialysis patients versus controls (p=0.000).
  • SCUBE1 levels increased significantly post-hemodialysis (p=0.000).
  • Positive correlation found between SCUBE1 and sCD40L (p=0.016).
  • Gender, blood pressure, BUN, creatinine, hsCRP, and dialysis parameters affected SCUBE1 levels.

Conclusions:

  • SCUBE1 is elevated in hemodialysis patients without clinical ischemic events.
  • This study is the first to report elevated SCUBE1 in hemodialysis patients.
  • Various factors associated with hemodialysis and patient health influence SCUBE1 levels.
Abstract

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