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Updated: May 19, 2026

Study of Protein-protein Interactions in Autophagy Research
Published on: September 9, 2017
Receptor protein complexes are in control of autophagy
Dalibor Mijaljica1, Taras Y Nazarko, John H Brumell
1Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University Clayton Campus, Victoria, Australia.
Abstract:
In autophagic processes a variety of cargos is delivered to the degradative compartment of cells. Recent progress in autophagy research has provided support for the notion that when autophagic processes are operating in selective mode, a receptor protein complex will process the cargo. Here we present a concept of receptor protein complexes as comprising a functional tetrad of components: a ligand, a receptor, a scaffold and an Atg8 family protein. Our current understanding of each of the four components and their interaction in the context of cargo selection are considered in turn.
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