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Granule cell dispersion is associated with memory impairment in right mesial temporal lobe epilepsy

Rafael Scarpa da Costa Neves1, Ivanda de Souza Silva Tudesco, Anaclara Prada Jardim

  • 1Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo SP, Brazil. rafaelscarpa@uol.com.br

Seizure
|August 10, 2012
PubMed
Abstract

Insights

Granule cell dispersion (GCD) is linked to poorer visuospatial memory in right mesial temporal lobe epilepsy (MTLE) with mesial temporal sclerosis (MTS). Its exact role in memory function requires further investigation.

Area of Science:

  • Neurology
  • Neuroscience
  • Pathology

Background:

  • Mesial temporal lobe epilepsy (MTLE) with mesial temporal sclerosis (MTS) is a common cause of drug-resistant epilepsy.
  • Granule cell dispersion (GCD), an indicator of hippocampal development, is frequently observed in MTLE-MTS.

Purpose of the Study:

  • To investigate the association between GCD and memory performance.
  • To explore the relationship of GCD with clinical data and surgical outcomes in MTLE-MTS patients.

Main Methods:

  • Hippocampal specimens from 54 MTLE-MTS patients and 13 controls were analyzed neuropathologically.
  • Patients were categorized into GCD and no-GCD groups.
  • Neuropsychological measures, clinical data, MTS type, and surgical outcomes were reviewed.

Main Results:

  • GCD was present in 51.9% of patients.
  • No correlation was found between GCD and MTS pattern, clinical data, or surgical outcome.
  • GCD correlated with worse visuospatial memory in right MTLE but not in left MTLE.

Conclusions:

  • GCD may contribute to memory impairment in patients with right MTLE-MTS.
  • The precise role of GCD in memory function remains to be fully elucidated.

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