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In Vitro Pancreas Organogenesis from Dispersed Mouse Embryonic Progenitors
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A Sox9/Fgf feed-forward loop maintains pancreatic organ identity

Philip A Seymour1, Hung Ping Shih, Nisha A Patel

  • 1Departments of Pediatrics and Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093-0695, USA.

Development (Cambridge, England)
|August 10, 2012
PubMed
Summary

The transcription factor Sox9 is essential for pancreas development. Its interaction with Fgf10 and Fgfr2b forms a crucial loop, maintaining organ identity and controlling progenitor cell growth.

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