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Spectral discrimination between normal and leukemic human sera using delayed luminescence.

Ping Chen¹, Lei Zhang, Feng Zhang

¹Institute of Modern Optics, Key Laboratory of Optical Information Science & Technology, Ministry of Education of China, Nankai University, Tianjin 300071, China.

Biomedical Optics Express

|August 10, 2012

Summary

Photoinduced delayed luminescence (DL) can differentiate acute lymphoblastic leukemia (ALL) serum from healthy serum. This optical method shows significant differences in decay rates for early leukemia diagnosis.

Keywords:

(170.0170) Medical optics and biotechnology (170.4580) Optical diagnostics for medicine (300.6280) Spectroscopy, fluorescence and luminescence

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Area of Science:

Biomedical optics
Medical diagnostics
Biochemistry

Background:

Acute lymphoblastic leukemia (ALL) is a significant health concern.
Early diagnosis of ALL is crucial for effective treatment.
Current diagnostic methods can be invasive or time-consuming.

Purpose of the Study:

To investigate the potential of photoinduced delayed luminescence (DL) for distinguishing ALL serum from healthy serum.
To establish an optical method for early leukemia detection.

Main Methods:

Utilized a homebuilt ultraweak luminescence detection system.
Measured DL decay kinetics of human serum samples.
Analyzed DL parameters: initial intensity, peak decay rate, and peak weight value.

Main Results:

A significant difference in decay rate distribution was observed between normal and leukemic serum samples.
Discrimination between normal and leukemic sera was achieved by comparing DL kinetics parameters.
The study demonstrated the feasibility of using DL for serum analysis.

Conclusions:

Photoinduced delayed luminescence (DL) offers a novel optical approach for leukemia diagnosis.
DL analysis of serum shows promise for early and non-invasive detection of ALL.
This technique contributes to the development of advanced diagnostic tools in oncology.