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Published on: December 14, 2021
[Study on the pharmacokinetics of ginkgolide B for injection in rats]
Xian-Tao Zhang1, Hao-Yan Jiao, Qi-Liang Suo
1Guangdong Research Institute of Traditional Chinese Medicine, Guangzhou 510520, China. zxtcpu@yahoo.com.cn
Objective:
To study the pharmacokinetics of ginkgolide B for injection in rats.
Methods:
The serum concentration of ginkgolide B was determined by LC-MS and calculate its parameter of pharmacokinetics via DAS2.0 software.
Results:
After intravenous of 0.75, 3.75 and 14.0 mg/kg ginkgolide B, parameters of pharmacokinetics of ginkgolide B were: Tmax were all (0.083 +/- 0) h, Cmax were (422.312 +/- 14.203), (1608.467 +/- 226.677), (1987.036 +/- 237.202) microg/L, AUC0-1 were (533.833 +/- 114.943), (1786.029 +/- 137.066), (1943.44 +/- 415.892) microg x h/L.
Conclusion:
Ginkgolide B has three compartment model in rats.
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