Related Experiment Video
Updated: May 19, 2026
09:32
Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity
Published on: October 17, 2025
Lapatinib and renal cell carcinoma.
Marine Gross-Goupil1, Jean-Christophe Bernhard, Alain Ravaud
1Hôpital Saint-Andre, Bordeaux University Hospital, Bordeaux University, Department of Medical Oncology, Bordeaux, France.
Expert Opinion on Investigational Drugs
|August 11, 2012
Summary
Despite advances in renal cell carcinoma (RCC) treatment, therapies remain largely palliative. Further drug development, like for lapatinib, requires a deeper understanding of molecular features for targeted patient selection.
Area of Science:
- Oncology
- Molecular Biology
- Pharmacology
Background:
- Renal cell carcinoma (RCC) treatment has seen significant advancements.
- The Epidermal Growth Factor Receptor (EGFR) pathway is being investigated for its role in RCC.
Purpose of the Study:
- To review the implication of the EGF/EGFR pathway in RCC.
- To summarize EGFR positivity data and clinical trial results for lapatinib in RCC.
Main Methods:
- Literature review of the EGF/EGFR pathway in RCC.
- Analysis of prospective Phase II and III trials involving lapatinib and other EGFR inhibitors.
Main Results:
- Data on EGFR positivity in RCC patients is variable.
- Clinical trial results for lapatinib in RCC are presented.
Conclusions:
- Current RCC treatments are mostly palliative despite progress.
- Targeted therapy requires understanding molecular tumor features.
- Further development of drugs like lapatinib is not supported without better biological knowledge.
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