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[Effects of ethylene glycol on hepatic microsomal cytochrome P-450]
K Fujishiro1, K Imazu, N Inoue
1Department of Environmental Toxicology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Journal of UOEH
|December 1, 1990
Abstract:
The effect of ethylene glycol on rat hepatic microsomal cytochrome P-450 was studied in vitro and in vivo. The destruction of cytochrome P-450 was not seen in vitro. The addition of 1 mM NADPH also did not change. When ethylene glycol was added to drinking water at a concentration of 1.0% for 7 days, there was no change in the contents of microsomal protein, cytochrome P-450, b5 and heme. While NADPH-cytochrome C reductase activity of the exposed group did not change, NADH-ferricyanide reductase activity increased significantly.