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Interaction between antimicrobial consumption and selection of resistant bacterial strains
1Department of Medicine, New England Deaconess Hospital, Boston, Massachusetts 02215.
Scandinavian Journal of Infectious Diseases. Supplementum
|January 1, 1990
Summary
Antimicrobial consumption, both therapeutic and prophylactic, is clearly linked to increased antimicrobial resistance in patients, hospitals, and globally. This complex relationship highlights the need for careful antimicrobial stewardship to combat rising resistance worldwide.
Area of Science:
- Microbiology
- Infectious Diseases
- Public Health
Background:
- Antimicrobial resistance (AMR) is a growing global health threat.
- The use of antimicrobial agents is a primary driver of AMR.
- Understanding the link between antimicrobial consumption and resistance is crucial for effective interventions.
Purpose of the Study:
- To summarize the evidence linking antimicrobial consumption to the emergence of bacterial resistance.
- To highlight the scope of this association across different settings.
Main Methods:
- Review of existing scientific literature and epidemiological data.
- Analysis of the correlation between antimicrobial usage patterns and resistance trends.
Main Results:
- Clear-cut evidence demonstrates a direct association between antimicrobial use and the development of resistance.
- This association is evident at the individual patient level.
- Resistance emergence is also observed within hospital environments and on a global scale.
Conclusions:
- Therapeutic and prophylactic antimicrobial use significantly contributes to the emergence of antimicrobial resistance.
- Effective antimicrobial stewardship programs are essential to mitigate this complex relationship and preserve antimicrobial efficacy.